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Permax (Pergolide)

Permax (Pergolide) and Heart Valve Disease

According to a report by doctors at the Mayo Clinic, Permax (pergolide) may be connected to heart valve disease. Pergolide, which is sold as Permax, has been used since 1989 to treat Parkinson's disease.

In three cases at the Mayo Clinic, three older women who were taking Permax daily for three to seven years were diagnosed with serious heart valve diseases. Two of these women had to have valve replacement surgery. Doctors at the Mayo Clinic say their evidence is enough to recommend that anyone with heart problems not take pergolide.

More than 500,000 people have taken Permax since it was approved by the FDA. The FDA has now contacted the drug's manufacturer about the latest reports of heart valve disease, and has recommended that the company change the labeling of pergolide.

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